Clinical observation on Danhong Injection combined with bispecific antibody therapy in treatment of malignant tumors and acute cerebral infarction
Objective To observe the efficacy of Danhong injection combined with bispecific antibody therapy in treatment of malignant tumors and acute cerebral infarction(MACI).Methods A total of 100 MACI patients were randomly divided into control group an observation group,with 50 cases in each group.Control group was treated with bispecific antibodies,and observation group was given Danhong Injection on the basis of control group.The total effective rate,neurological deficit scores[stroke,National Institutes of Health Scale(NIHSS),modified Rankin score(MRS)],blood rheological indexes[whole blood low cut viscosity(WBLV),whole blood high cut viscosity(WBHV),plasma viscosity(PV),hematocrit(Hct)],coagulation indicators[prothrombin time(PT),partial thromboplastin time(APTT),thrombin time(TT),fibrin(FIB),D-dimer(D-D)],lipid markers[total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C)]in the two groups were compared.Results After treatment,the total effective rate of observation group was higher than that of control group(P＜0.05);the scores of NHISS and MRS in both groups were lower than those before treatment,and were lower in observation group than control group(P＜0.05);the scores of WBHV,WBLV,and PV in both groups were lower than those before treatment,and were lower in observation group than control group(P＜0.05);there was no significant difference in Hct between the two groups before and after treatment(P＞0.05);the PT,APTT,and TT levels in both groups were higher than those before treatment,while the FIB and D-D were lower,and the above indexes were superior in observation group to those in control group(P＜0.05);the TC and TG of both groups were lower than those before treatment,while the HDL-C was higher,and the above indexes were superior in observation group to those in control group(P＜0.05).Conclusion Danhong Injection combined with bispecific antibody therapy can improve the neurological function and regulate the hemorheology,coagulation and blood lipid levels in patients with MACI.
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