The effectiveness of Wumei Pills combined with mesalazine in treatment of ulcerative colitis
Objective To observe the efficacy of Wumei Pills combined with mesalazine in patients with ulcerative colitis(UC).Methods Sixty UC patients were randomly divided into a study group and a control group,with 30 cases in each group.Control group was treated with mesalazine,while study group was treated with Wumei Pills on the basis of control group.The therapeutic effects,Baron's standard score for endoscopy,disappearance time of fever,abdominal pain,diarrhea,pus,and blood stool,TCM syndrome score,interleukin-10(IL-10),1L-4,IL-17,interferon-y(INF-y),diamine oxidase(DAO),D-lactate,endotoxin content,and gut microbiota count were compared between the two groups.Results After treatment,the total effective rate of study group was higher than that of control group(P＜0.05);the Baron scores of both groups were lower than before treatment,and were lower in study group than control group(P＜0.05);study group had shorter disappearing time of fever,abdominal pain,diarrhea,and bloody stool than control group(P＜0.05);TCM syndrome scores,1L-17 and INF-y,DAO,D-lactate,endotoxin content,Enterococcus and Escherichia coli indexes were lower than those before treatment in both groups,and were lower in study group than control group(P＜0.05);the levels of IL-10 and IL-4,Bifidobacterium and Lactobacillus indexes in both groups were higher than before treatment,and were higher in study group than control group(P＜0.05).Conclusion The combination of Wumei Pills and mesalazine has a significant therapeutic effect on UC patients,promoting the disappearance of Western and TCM symptoms,improving endoscopic manifestations,reducing inflammatory reactions,balancing gut microbiota,protecting intestinal mucosal barrier,regulating the balance of Thl,Th2,and Th17 factors,and promoting immune function recovery.
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