Study on the efficacy of acupoint application combined with proton pump inhibitors in treatment of gastroesophageal reflux disease
Objective To observe the efficacy of acupoint application combined with proton pump inhibitors(PPIs)in treatment of gastroesophageal reflux disease(GRD).Methods A total of 130 GRD patients were randomly divided into observation group and control group,with 65 cases in each group.Control group was treated with PPI,and observation group was treated with acupoint application on the basis of control group.The total effective rate,Los Angeles grading criteria,TCM pattern score,quality of life scale score,24 h reflux time ≥5 min times,pH＜4time,upper esophageal sphincter resting pressure(UESP),lower esophageal sphincter resting pressure(LESP),secretin(GAS),vasoactive intestinal peptide(VIP),interleukin-6(IL-6)and C-reactive protein(CRP)were compared between the two groups.Results After treatment,the total effective rate of observation group was higher than that of control group(P＜0.05);the Los Angeles esophageal grade in both groups was better than that before treatment,and were better in observation group than control group(P＜0.05);the TCM pattern scores,24 h reflux time ≥ 5 min times,pH＜4time,VIP,IL-6 and CRP content of both groups were lower than those before treatment,and were lower in observation group than control group(P＜0.05);the quality of life scale scores,UESP,LESP,and GAS contents in both groups were higher than those before treatment,and were higher in observation group than control group(P＜0.05).Conclusion Acupoint application combined with PPI has excellent short-term efficacy in treatment of GRD,promoting the recovery of esophageal mucosa,reducing TCM pattern scores,reducing the number of reflux and pH＜4 time,improving quality of life,restoring esophageal sphincter resting pressure,regulating gastrointestinal hormones,and reducingpro-inflammatory factor levels.
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