Effect observation on electroacupuncture combined with mifepristone on dysmenorrhea caused by adenomyosis
Objective To observe the efficacy of electroacupuncture(EA)combined with mifepristone in treatment of dysmenorrhea(AD)in adenomyosis.Methods A total of 140 AD patients were randomly divided into control group and ob-servation group with 70 cases in each group.Control group was given oral mifepristone,and observation group was given EA on the basis of control group.The clinical efficacy,interleukin-6(IL-6),prostaglandin F2α(PGF2α),β-endorphins(β-EP),carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199),endometrial thickness,uterine volume,Visual Analogue Scale(VAS)score,menstrual blood loss chart(PBAC),COX Dysmenorrhea Symptom Assessment Scale(CMSS),estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH)levels,and the recurrence rate of the two groups were compared.Results After treatment,the total effective rate of observation group was higher than that of control group(P＜0.05);IL-6,PGF2α,CA125 and CA199 levels in both groups were lower than those before treatment,while B-EP levels were higher,the above indicators were superior in observation group to those in control group(P＜0.05);endometrial thickness,uterine volume,VAS,PBAC,and CMSS scores in both groups were lower than those before treatment,and were lower in observation group than control group(P＜0.05);E2,LH and FSH levels in both groups were lower than those before treatment,and were lower in observation group than control group(P＜0.05);the recurrence rate of observation group was lower than that of control group(P＜0.05).Conclusion EA combined with mifepristone can improve the efficacy of AD,improve the structure of the uterus,reduce the degree of dysmenorrhea,reduce inflammation,regulate the levels of sex hormones and related factors.and reduce recurrence.
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