Clinical observation on self-made Yishen Zigan Prescription in treatment of Parkinson's disease with liver and kidney yin deficiency type
Objective To observe the effect of Yishen zigan Prescription in treating Parkinson's disease(PD)on with liver and kidney yin deficiency type.Methods Sixty patients with liver and kidney yin deficiency type PD were randomly divided into control group and observation group,30 cases in each group.Control group was given levodopa,and observation group was added with self-made Yishen Zigan Prescription on the basis of control group.The clinical efficacy,Parkinson's Disease Rating Scale(UPDRS)score,TCM Syndrome Scale score,main syndrome score,serum Hcy,Hs-CRP,uric acid levels and adverse reactions of the two groups were compared after treatment.Results The total effective rate in observation group was significantly higher than that of control group(P＜0.05);UPDRS,PDQ-39 and TCM Syndrome Scale scores in both groups were lower than before treatment,and were lower in observation group than control group(P＜0.05);serum Hcy and hs-CRP in observation group were lower than before treatment(P＜0.05),and were lower in observation group than control group(P＜0.05);while the changes in control group were not significant(P＞0.05),serum uric acid levels in both groups was higher than before treatment,and was higher in observation group than control group(P＜0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Self-made Yishen Zigan Prescription has good clinical efficacy,high safety,and small toxic side effects in treating PD with liver and kidney yin deficiency type.It is recommended to promote application.
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