摘要
目的 观察益补逐瘀汤联合西医治疗气阴两虚夹瘀型早期糖尿病肾病(EDN)临床疗效.方法 将我院124例EDN患者随机分为对照组与观察组各62例.对照组采用西医疗法,观察组采用益补逐瘀汤联合西医疗法.比较两组临床疗效及空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2h血糖(2hPG)、血肌酐(Scr)、血尿素氮(BUN)、肾小球滤过率(GFR)、24 h尿蛋白定量(24 hUPO),尿液podocin、nephrin,中医证候评分.结果 治疗后,观察组总有效率高于对照组(P＜0.05);两组FPG、HbA1c、2 hPG低于治疗前,观察组上述指标低于对照组(P＜0.05);两组Scr、BUN、24 hUPO低于治疗前,GFR高于治疗前;观察组Scr、BUN、24hUPO低于对照组,GFR高于对照组(P＜0.05);两组尿液podocin、nephrin低于治疗前;观察组上述指标低于对照组(P＜0.05);两组中医证候评分低于治疗前,观察组中医证候评分低于对照组(P＜0.05).结论 益补逐瘀汤联合西医治疗气阴两虚夹瘀型EDN患者疗效显著,能降血糖,改善肾功能,降低尿液足细胞损伤指标水平,改善中医证候.
Abstract
Objective To observe the clinical efficacy of Yibu Zhuyu Decoction combined with Western medicine in treatment of early diabetic nephropathy(EDN)with qi and yin deficiency and stasis.Methods A total of 124 EDN patients were randomly divided into control group and observation group,with 62 cases in each group.Control group was treated with Western medicine,and observation group was treated with Yibu Zhuyu Decoction on the basis of control group.The efficacy fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),2 h postprandial blood glucose(2 h PG),serum creatinine(Scr),blood urea nitrogen(BUN),glomerular filtration rate(GFR),24 h urine protein quantification(24 h UPO),urine podocin,nephrin,and various TCM syndrome scores before and after treatment of the two groups were compared.Results After treatment,the total effective rate of observation group was higher than that of control group(P＜0.05);the levels of FPG,HbA1c and 2 hPG in both groups were lower than those before treatment,and were lower in observation group than control group(P＜0.05);Scr,BUN,and 24 h UPO in both groups were lower than those before treatment,while GFR was higher,and the above indicators were superior in observation group to those in control group(P＜0.05);the urine podocin and nephrin in both groups were lower than those before treatment,and were lower in observation group than control group(P＜0.05);the scores of TCM in both groups were lower than those before treatment,and were lower in observation group than control group(P＜0.05).Conclusion Yibu Zhuyu Decoction combined with Western medicine is remarkable in treatment of EDN patients with qi and yin deficiency and stasis,which can reduce blood sugar,improve kidney function,reduce the level of urine podocyte lesions,and improve TCM syndromes.
基金项目
河北省中医药管理局中医药类科技计划项目(2018198)
河北省中医药管理局科研计划项目(2023179)
NETL
NSTL
万方数据