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苍术的药代动力学研究进展

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苍术作为临床常用中药,前人对其化学成分和药理作用进行了大量的研究,苍术及其所含成分的药代动力学研究虽取得了一些进展,但仍然比较零散,不够系统和全面.本文通过系统整理与归纳,对苍术中的主要化学成分苍术素、β-桉叶醇、苍术酮、白术内酯类、苍术苷类、异绿原酸类的药代动力学研究概况进行综述,初步明确了苍术主要成分药代动力学的代谢规律,为指导临床用药提供科学依据.
Research Progress on pharmacokinetics of Rhizoma Atractylodis
Rhizoma Atractylodis,as a commonly used traditional Chinese medicine in clinic,has been extensively studied for its chemical constituents and pharmacological effects,although the pharmacokinetic study of Rhizoma Atractylodis and its components has made some progress,it is still relatively fragmented and not systematic and comprehensive.In this paper,the pharmacokinetics of atractylodin,β-eudesmol,atractylone,atractylodes,atractylosides,and isochlorogenic acids,and the main chemical components of Rhizoma Atractylodis were reviewed,the metabolic law of the pharmacokinetics of the main components of Rhizoma Atractylodis was preliminarily clarified,providing a scientific basis for guiding clinical medication.

Rhizoma AtractylodisChemical componentsMetabolismPharmacokinetics

严恒、季新洋、冯施慧、张傲蕾、瞿领航

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湖北中医药大学药学院,湖北武汉 430065

苍术 化学成分 代谢 药代动力学

湖北省教育厅科学研究计划青年人才项目国家自然科学基金青年项目湖北省自然科学基金联合项目

Q20232006823047222023AFD154

2024

湖北中医药大学学报
湖北中医药大学

湖北中医药大学学报

CSTPCD
影响因子:0.873
ISSN:1008-987X
年,卷(期):2024.26(5)
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