Effect of Yiqi Huoxue Prescription combined with dual antiplatelet aggregation on unstable angina pectoris after PCI for coronary heart disease
Objective To observe the effect of Yiqi Huoxue Prescription combined with dual antiplatelet aggregation on unstable angina pectoris(UA)after percutaneous coronary intervention(PCI)for coronary heart disease(CHD).Methods A total of 84 patients with UA after PCI for CHD were randomly divided into control group and treatment group,with 42 cases in each group.Control group was treated with dual antiplatelet aggregation therapy,while treatment group was treated with Yiqi Huoxue Prescription on the basis of control group.The total effective rate,total TCM syndrome score,Seattle angina survey scale(SAQ),number of ischemic attacks,total ischemic time,maximum duration,number of premature ventricular contractions,nitric oxide(NO),endothelin-1(ET-1),high-sensitivity C-reactive protein(hs-CRP),low-density lipoprotein cholesterol(LDL-C),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),total cholesterol(TC),adenosine diphosphate(ADP),and arachidonic acid(AA)inhibition rate were compared between the two groups.Results After treatment,the total effective rate of treatment group was higher than that of control group(P＜0.05);the total TCM syndrome scores in both groups were lower than those before treatment,while the SAQ scores were higher,and the above indicators were superior in treatment group to those in control group(P＜0.05);the number of ischemic episodes,total ischemic time,maximum duration,and the number of premature ventricular contractions in both groups were lower than those before treatment,which were lower in treatment group than control group(P＜0.05);the NO in both groups was higher than that before treatment,while the ET-1 and hs-CRP were lower,and the above indicators were superior in treatment group to those in control group(P＜0.05);the TG,TC,and LDL-C in both groups were lower than those before treatment,while the HDL-C was higher,and the above indicators were superior in treatment group to those in control group(P＜0.05);there was no significant difference in the AA inhibition rate and ADP inhibition rate between the two groups(P＞0.05).Conclusion Yiqi Huoxue Prescription combined with dual antiplatelet aggregation can improve the efficacy of UA patients after PCI for coronary heart disease,which can improve quality of life and electrocardiogram activity,and regulate dyslipidemia.
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