Efficacy of Simo Decoction combined with Bacillus subtilis double viable bacteria granules in treatment of neonatal hypoxic-ischemic encephalopathy with digestive system injury
Objective To observe the efficacy of Simo Decoction combined with Bacillus subtilis double viable bacteria granules in treatment of neonatal hypoxic-ischemic encephalopathy(HIE)with digestive system injury.Methods A total of 102 HIE with digestive system injury neonatal patients were randomly divided into control group and observation group,with 51 cases in each group.Control group was treated with Bacillus subtilis double viable bacteria granules,while observation group was treated with Simo Decoction on the basis of control group.The efficacy,Neonatal Behavioral Neuroassessment(NBNA)score,DQ score of each item,reflex,consciousness recovery,muscle tone recovery time,gastrointestinal disease TCM symptom score,and Lactobacillus and Enterobacter colony counts of the two groups was compared.Results After treatment,the total effective rate of observation group was higher than that of control group(P＜0.05);the NBNA scores in both groups were higher than those before treatment,which were higher in observation group than control group(P＜0.05);the DQ scores of each item in both groups were higher than those before treatment,which were higher in observation group than control group(P＜0.05);the reflex,consciousness,and muscle tone recovery time in observation group were shorter than those in control group(P＜0.05);the TCM symptom scores of gastrointestinal diseases in both groups were lower than those before treatment,which were lower in observation group than control group(P＜0.05);the number of colonies of Lactobacillus in both groups was higher than that before treatment,which was higher in observation group than control group,while the number of colonies of Enterobacteriaceae was lower in both groups than that before treatment,which was lower in observation group than control group(P＜0.05).Conclusion Simo Decoction combined with Bacillus subtilis double viable bacteria granules can significantly improve the efficacy of neonatal HIE with digestive system injury,promote the recovery of behavioral neural ability,enhance intellectual development,alleviate digestive system damage,and improve intestinal colonization.
Hypoxic-ischemic encephalopathyNeonatalDamage to the digestive systemSimo DecoctionBacillus subtilis double viable bacteria granules
NETL
NSTL
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