Study on the preparation process of Jingtian Granule
Objective To optimise the best preparation process of Jingtian Granule.Methods The extraction process was preferred by orthogonal experimental design with the comprehensive scores of paste yield and Salidroside content as the indexes;the optimal concentration strength and drying parameters were preferred with the content of rhodiola rosea glycoside,the yield of dry paste powder and its properties as the indexes;the optimal dry granulation parameters were preferred with the hygroscopicity rate and one-time moulding rate as the indexes,and the auxiliary dosage was investigated by one-way test and orthogonal experimental method.Results The optimal preparation process was as follows:add 8 times the weight of the decoction pieces in water,soak for 30 min,and decoct twice,each time for 2 h,combined filtrate.The filtrate was concentrated under reduced peressure at 60～70℃ to a clear paste with a relative density of 1.08～1.11(60℃).The decoction was decompressed at 60～70℃ to a concentrate with a relative density of 1.08～1.11(60℃),and then add 5％maltodextrin of the weight of the tablets to be spray dried,and then adjust the drying inlet temperature of 180℃ to collect the powder;add the appropriate amount of maltodextrin,mix well,and then dry granulate,i.e.,to obtain a dry granule.The powder was collected;appropriate amount of maltodextrin was added,mixed well,and dry granulation was carried out,which was obtained.Conclusion The preparation process of Jingtian Granule established in this study is stable and feasible with controllable quality,which can provide a basis for pharmacological research for the development of its in-hospital preparation.
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