The therapeutic effect of Liangxue Wuhua Decoction combined with cetirizine on facial hormone dependent dermatitis
Objective To observe the efficacy of Liangxue Wuhua Decoction combined with cetirizine in treatment of facial hormone dependent dermatitis(FHDD).Methods Eighty cases of FHDD were randomly divided into control group and observation group,with 40 cases in each group.Control group was treated with cetirizine,while observation group was treated with Liangxue Wuhua Decoction on the basis of control group.The clinical efficacy of two groups,including rebound time,rebound duration,sensitivity symptoms,quality of life index(DLQI),skin color,area,itching score,stratum corneum water content(SCH),pH,transcutaneous water loss(TEWL),interleukin-4(IL-4),immunoglobulin E(IgE),IL-6,and IL-8 levels,and recurrence rate were compared.Results After treatment,the total effective rate of observation group was higher than that of control group(P＜0.05);observation group had lower rebound time and rebound duration than control group(P＜0.05);the sensitivity symptoms and DLQI scores of both groups were lower than before treatment,which were lower in observation group than control group(P＜0.05);the skin color,area,and itching scores of both groups were lower than before treatment,which were lower in observation group than control group(P＜0.05);the levels of SCH in both groups were higher than before treatment,which was higher in observation group than control group,while pH and TEWL were lower,which were lower in observation group than control group(P＜0.05);the levels of IL-4,IgE,IL-6,and IL-8 in both groups were lower than before treatment,which were lower in observation group than control group(P＜0.05);the recurrence rate of observation group was lower than that of control group(P＜0.05).Conclusion Liangxue Wuhua Decoction combined with cetirizine can improve sensitive symptoms,restore skin barrier function,reduce inflammatory reactions,and reduce recurrence in treatment of FHDD.
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