Efficacy of acupuncture combined with celecoxib in treatment of knee osteoarthritis complicated with degenerative lumbar spondylosis and its effect on pain
Objective To observe the efficacy of acupuncture combined with celecoxib in treatment of knee osteoarthritis complicated with degenerative lumbar spondylosis(KOADLS)and its effect on pain.Methods A total of 150 cases of KOADLS patients were randomly divided into control group and observation group,with 75 cases in each group.Control group was treated with celecoxib,while observation group was treated with acupuncture on the basis of control group.The clinical efficacy of the two groups was compared,including Osteoarthritis Index(WOMAC),Quality of Life Measurement Scale(QOL-BREF)score,Lysholm knee joint,Japan Orthopaedic Association(JOA)evaluation for the treatment of low back pain score,Visual Analogue Scale(VAS)score,whole blood viscosity low-cut,medium-cut,and high-cut,interleukin-1β(IL-1β),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)levels.Results After treatment,the total effective rate of observation group was higher than that of control group(P＜0.05);the WOMAC score of both groups was lower than that before treatment,which was lower in observation group than control group;the QOL-BREF score was higher in both groups than that before treatment,which was higher in observation group than that of control group(P＜0.05);the scores of Lysholm knee joint and JOA low back pain in both groups were higher than those before treatment,which were higher in observation group than control group,while the VAS scores in both groups were lower than those before treatment,which were lower in observation group than control group(P＜0.05);the viscosity of whole blood in both groups was lower than that before treatment,which was lower in observation group than control group(P＜0.05);the levels of IL-1 β,CRP,and TNF-α in both groups were lower than those before treatment,which were lower in observation group than control group(P＜0.05).Conclusion Acupuncture combined with celecoxib has significant efficacy in treatment of KOADLS,which can improve the function of knee joint and lumbar spine,improve quality of life,reduce pain,reduce blood viscosity,and inhibit inflammatory response.
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