用循环拆分法制备手性萘乙胺
Preparation of Chiral Naphthylethylamines by Recycling Resolution
胡键 1董菁 1施小新1
作者信息
- 1. 华东理工大学,药学院,上海,200237
- 折叠
摘要
研究了1-(1-萘基)乙胺[(RS)-1]和1-(2-萘基)乙胺[(RS)-2]的循环拆分方法.以D-酒石酸为拆分剂,分别拆分(RS)-1和(RS)-2得到了(R)-1-(1-萘基)乙胺(收率31%,98%ee) 和(R)-1-(2-萘基)乙胺(收率30%,98%ee),并对母液中的非目标对映异构体成功的进行了消旋化,实现了循环拆分.
Abstract
The recycling resolution of (RS)-1-(1-naphthyl)ethylamine[(RS)-1] and (RS)-1-(2-naphthyl)ethylamine[(RS)-2] was studied in this paper.(R)-1-(1-naphthyl)ethylamine(31% yield,98%ee) and (R)-1-(2-naphthyl)ethylamine(30% yield,98%ee) were obtained via resolution of the racemic (RS)-1 and (RS)-2 by using D-tartaric acid as a resoluting agent.Meanwhile racemization of the non-target enantiomeric isomers from mother liquor was performed,and the recycling resolution was realized.
关键词
萘乙胺/拆分/循环拆分/消旋Key words
naphthylethylamine/resolution/recycling resolution/racemization引用本文复制引用
基金项目
国家自然科学基金(20972048)
上海市教育发展基金(03SG27)
出版年
2010
NETL
NSTL
维普
万方数据