The reported synthesis route of chiral aldehyde catalysts(3)has a low total yield and is not suitable for 3 in mass synthesis.Therefore,the synthetic route of 3 is improved.Using(S)-1,1'-bidi-naphthol((S)-BINOL)as raw material,chiral aldehyde catalysts(3a～3i)were synthesized within 10 steps including sulfonylation,carbonylation,coupling,boration,oxidation,protection,reduction,oxi-dation,deprotection,and bromination.Most of the catalysts can be obtainded in a total yield over 20%.This procedure is also suitable on a 10 mmol scale synthesis,which provides a good synthetic application prospect.
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