Research Progress on Synthetic Routes of Vitamin E
Vitamin E is a fat-soluble vitamin compound,which has many activities such as maintaining beauty,anti-aging,anti-sterility,anti-oxidation,anti-cancer,etc.Therefore,the exploration of the synthetic route of Vitamin E is the focus of pharmaceutical researchers.Vitamin E is a natural chemical with 2 structures of tocopherol and trienol,and each structure include 4 kinds of configuration(α,β,γ and δ),of which α-tocopherols display the highest activity and the best effect.Due to the wide appli-cation of Vitamin E in the field of medicine and the large market demand,the production of natural Vi-tamin E cannot meet the clinical demand.In order to further expand the production of Vitamin E,the researchers have developed a series of total synthetic methods of these compounds.In this paper,the reported synthetic methods of Vitamin E are summarized mainly from the modification of parent ring and side chain,providing reference for the further improvement of the process of Vitamin E.
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