Synthesis and Anticancer Activity of Novel Porphyrin-swainsonine Derivatives
New research into anticancer drugs is increasingly gaining attention.In this paper,seven new swainsonine derivatives(1a～1g)were synthesized by the condensation of aminoporphyrin or hy-droxyl porphyrin,POCl3 and swainsonine,and their antitumor activities were evaluated.The results showed that derivatives 1a～1g all had inhibitory effects on SGC-7901 and Eca-109 tumor cells.The IC50 of derivative 1c for SGC-7901 and Eca-109 cells was 1.77±0.14 μM and 3.32±0.13 μM,re-spectively,which clearly indicates superior anticancer activity compared to swainsonine.The structures of all derivatives were confirmed by nuclear magnetic resonance,mass spectrometry and elemental analysis.
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