Progress in New Methods for Construction of 1,3,5-Triazine Ring
1,3,5-triazine compounds exhibit various biological activities,such as anti-tumor,antibac-terial,anti-inflammatory,etc.At present,several anti-tumor drugs with 1,3,5-triazine as pharma-cophore have been approved by FDA or entered the clinical research.Therefore,the synthesis methods of these compounds have attracted considerable attention.This paper summarize new methods for the construction of 1,3,5-triazine ring in recent years.These reactions could be classified into three parts according to the different raw materials,using amidine compounds guanidine compounds as raw materi-als and other starting materials.These new methods mainly through[1 +2 +3](with amidine com-pounds as raw materials)or[1 +5](with guanidine compounds as raw materials)coupling annula-tions for construction of triazine ring and feature highly atom economical,environmentally friendly,op-eration conveniently and higher conversion.The summary and induction of new methods for the prepa-ration of 1,3,5-triazine will provide inspiration for the construction and derivatization of 1,3,5-triazine rings.
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