BMS986202,a potent,selective and orally active TYK2 inhibitor is remarkably selective o-ver other kinases including JAK family members and it can be used for the treatment of IL-23-driven acanthosis,anti-CD40-induced colitis,and spontaneous lupus,which has a good prospect of develop-ment and application.The improved synthetic route of BMS986202 has been developed.By using 1-bromo-2-methoxy-3-nitrobenzene as staring material,BMS986202 was obtained through four steps in-cluding reduction,coupling,arylation and amidation.The total yield was increased to 85％and the structure of product was characterized by 1H NMR and MS(ESI).The results showed that with the ad-vantages of mild reaction condition,simple step,convenient to handle,this route is suitable for the in-dustrial production.
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