Ring Opening Reaction of Donor Acceptor Cyclopropane Diesters with Anilines
γ-aminobutyric acid is an important structural unit of many biologically active compounds,and it is of great significance to develop novel and simple methods for the synthesis of these com-pounds.In this paper,seventeen γ-arylamino-γ-phenylbutyrates were synthesized with donor-acceptor cyclopropanes and anilines as raw materials,Yb(OTf)3 as catalyst and THF as solvent at 30 ℃ for 4.5 h,with 67％～93％yield.This strategy has the advantages of mild reaction conditions,and wide uni-versality of substrates,and can be used for the convenient synthesis of y-arylamino-y-phenylbutyrate compounds.
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