Thionyl Chloride-activated Homo-coupling Reaction of Aryl Hydrazine
As a class of important aromatic compounds,biaryl hydrocarbons are widely used in the fields of medicine,materials,and chemistry.It is significant to develop novel and simple methods for synthesizing aryl-aryl compounds.In this paper,aryl hydrazine hydrochloride was used as the raw ma-terial.By screening different amounts of bases,solvents,and activators,an optimal experimental con-dition was optimized:4-dimethylaminopyridine as the promoter,acetonitrile as the solvent,1.5 equiv-alents of dichlorosulfoxide as the activator.Under these conditions,11 biphenyl derivatives were syn-thesized in 5 minutes with yields ranging from 24％～68％.The target compounds were confirmed by 1H NMR and 13 C NMR.This method has the advantages of mild reaction conditions and no need for transition metal catalysis.
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