Synthesis and Photothermal Properties of Polyaryl Aza-BODIPY
Near-infrared organic dyes with high photothermal efficiency have a promising application in the field of photothermal therapy.In this article,we take Aza-BODIPY as the research object,and synthesize three polyarylaza BODIPY compounds by using bromination and Suzuki coupling reaction.Explore the relationship between the maximum absorption peaks and photothermal properties with the number of aromatic groups of these three Aza-BODIPY compounds.In CH2Cl2,the maximum absorp-tion peaks of four to six aryl Aza-BODIPY are tested to be 691 nm,684 nm and 680 nm.This results indicating that with the increase of the aryl group of Aza-BODIPY,the absorption spectrum of the com-pounds does not show a significant red-shifted.Photothermal experiments have shown these Aza-BODIPY compounds have high photothermal conversion efficiency.When prepared into a solution of 20μg/mL using dimethyl sulfoxide as a solvent,the photothermal conversion efficiency is 75.4％,77.3％,and 76.8％,respectively.The effect of aryl in 2,6-position of Aza-BODIPY on photothermal is limited.It may be because increase the number of aryl groups will cause the crowding between the groups,so that the rotation of the groups was blocked,and the increase of photothermal conversion efficiency was not significant.This paper proved that the introduction of aryl group at the 2,6-position of Aza-BODIPY can't redshift the spectrum,but can slightly improve the photothermal conversion efficiency.
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