Improved Synthetic Process of 2-Cyanophenylhydrazine
2-cyanophenylhydrazine was widely applied in the field of drug development.In this study,the target compound was synthesized from 2-halogenated benzonitrile and hydrazine group via substitu-tion reaction.By optimizing the synthesis process,2-fluorobenzonitrile was selected as the raw material and reacting with hydrazine hydrate in one step to synthesize 2-cyanophenylhydrazine.When the con-centration of hydrazine hydrate was 80％and its dosage was 8 times of the amount of 2-fluorobenzoni-trile,2-cyanophenylhydrazine reached the highest yield of 82.4％.
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维普
