Suvorexant,first developed and marketed by Merck & Co.,is the first approved orexin re-ceptor antagonist for the clinical treatment of insomnia characterized by difficulty in sleep onset and/or sleep maintenance.In this paper,the synthetic routes of suvorexant will be analyzed,summarized and into two categories.The first type is fragment splicing.In the synthesis method of fragment splicing,the key chiral intermediates are prepared by resolution method and chiral starting material method.The chiral starting material method has good industrialization value due to high yield,since it does not re-quire separating the material.The second kind of synthesis method is sequential synthesis,in which ruthenium catalysis has a higher yield,while enzyme catalysis avoids the use of halogenated solvents and heavy metals,which accords with the concept of green chemistry and has more advantages in fu-ture development.The relevant routes summarized in this paper provide a reference for its industrializa-tion.
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