Palladium Catalyzed Synthesis of N-Aryl-γ-amino-γ-lactams
The γ-lactams are core structural units of a number of compounds with biological and medic-inal activities.The reported reactions of transition metal-catalyzed direct synthesis of N-aryl-γ-amino-γ-lactams suffer from limitation of peroxides and operating inconvenience.10％(molar fraction,same below)Pd/C was used as catalyst.The reactions of aryl amines with N-methyl-2-pyrrolidone were con-ducted in xylene at 100 ℃ for 24 h in an air atmosphere and gave N-aryl-γ-amino-γ-lactam compounds(3a～3g)in up to 91％yield.The structures of the products were confirmed by 1H NMR,13 C NMR and HR-MS(ESI)analysis.
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