Research Progress in The Synthesis of 1,2-Cis-2-amino-2-deoxy-glycoside Using 2-Nitroglucene as Intermediate
The development of glyco-vaccines have received much attention in recent years because of their role in preventing diseases such as pneumonia,meningitis and infant septicaemia.1,2-Cis-2-ami-no-2-deoxy-glycoside is an important sugar derivative,and many sugar conjured vaccines contain this compound structure,which plays a critical role in the development of sugar vaccines.The synthesis of 1,2-cis-2-amino-2-deoxy-glycoside via 2-nitroglyals is relatively mild and environmentally friendly.It is an ideal precursor for the synthesis of 1,2-cis-2-amino-2-deoxy-glycoside,and it is necessary to de-velop an efficient synthesis method of 2-nitroglyals.This paper summarizes the progress in the synthesis of 2-nitroglyals and the synthesis of 1,2-cis-2-amino-2-deoxyglycosides using 2-nitroglyals as intermedi-ates.and it is expected to provide theoretical reference for sugar vaccine development.
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