Synthesis of Three Major Metabolites of Pyroxasulfone
In order to meet the needs of toxicological tests for the metabolites of the herbicide Pyroxas-ulfone,the present study designed and optimized the synthetic pathways of the three main metabolites of Pyroxasulfone,M1,M3 and M4.Through a novel synthetic pathway,M1,M3 were successfully synthesized from 4-(chloroMethyl)-5-(difluoroMethoxy)-1-Methyl-3-(trifluoroMethyl)-1 H-pyrazole af-ter a series of reaction steps.M4 was successfully synthesized from Methacrylic acid and 1,1-Dibromo-formaldoxime after a number of reactions.The structure and purity of the metabolites were investigated by NMR-hydrogen spectroscopy(NMR-hydrogen spectrometry),liquid mass spectrometry(LMMS),and high-performance liquid chromatography(HPLC).The structure and purity of the metabolites were determined.After optimizing the synthesis process,the yields of M1,M3 and M4 reached 76.9％,82.5％and 70.1％,respectively.The purity of the synthesized metabolites could reach more than 97％.In the present study,these three Pyroxasulfone metabolites were successfully designed and pre-pared from the perspective of synthetic routes for the first time,which provides an important research basis for the fields of pesticide registration and quality control of pesticide residues.
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