Rhein(RH)can promote intestinal excretion of uric acid,improve kidney injury and reduce serum uric acid level.Taurine(T)can repair kidney damage,reduce xanthine oxidase(XOD)activi-ty,and also lower serum uric acid levels.Therefore,the two compounds have similar pharmacological activities in reducing uric acid and improving renal injury.The compound of rhein-taurine(T-RH)was synthesized by the combination of RH and T by amide bond to play a synergistic role.The chemical structure of T-RH was characterized by 1H NMR,13C NMR,IR,and MS(ESI).The inhibitory effect of T-RH on XOD in vitro was investigated.The results showed that T-RH was successfully synthesized and the yield was 65.73％.The inhibitory effect of T-RH on XOD in vitro was significantly better than RH(**P<0.01)and T(##P<0.01),and the inhibitory activity was positively correlated with the concentration of T-RH.
维普
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