Schiff base is a class of excellent ligand,and poses interesting bioactivities such as antibac-terial,antioxidation and antineoplastic etc.Two p-hydroxybenzaldehyde Schiff bases,(p-hydroxybenz-aldehyde)-(4-methyl-2-aminopyridine)(1)and(p-hydroxybenzaldehyde)-(5-methyl-2-aminopyri-dine)(2),were prepared with p-hydroxybenzaldehyde used as raw material,which reacts with 4-meth-yl or 5-methyl-2-aminopyridine,respectively.The structures of the products were characterized by melting point,IR spectrum,UV-Vis spectrum,1 H NMR,13 C NMR and high resolution mass spec-trometry.The antibacterial activity of compound 1 and 2 was studied by microbroth dilution method,which showed that the minimum inhibitory concentration(MIC)against E.coli,S.Aaureus and B.subtilis,V.is 0.50 mg/mL,while that against alginolyticus and V.parahemolyticus is 0.25 mg/mL.The antioxidant activity of 1 was investigated by DPPH·method,which indicated that the scavenging rate of 1 on DPPH·free radical is 68.1%.
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