Copper Salt-catalyzed Decarboxylative Amination of 5-Ethynyl-oxazolidine-2,4-dione and Aromatic Primary Amines
Alpha-tetrasubstituted amino acid derivatives,as a class of important non-natural amino acid moieties,are widely found in drug molecules,natural products and biologically active molecules.The copper-catalyzed decarboxylation of ethynyl-substituted cyclic carbonate or carbamate is a hot topic in organic chemistry.In this article,we have designed and synthesized the substrate of 5-ethynyloxazo-lidine-2,4-diones(EODO).The copper-catalyzed decarboxylative propargylic amination reaction be-tween EODO and aromatic primary amines enables the synthesis of twelve novel α-tetrasubstituted ami-no acid derivatives(3a～3l)with good to excellent yields(58％～94％).The products were charac-terized by 1H NMR,13 C NMR and HR-MS(ESI-TOF).
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