Design,Synthesis and Anti-lung Fibrosis Activities Evaluation of Novel Imidazo[1,2-a]-pyridine Derivatives
Imidazole[1,2-a]-pyridine is an important nucleus for maintaining the activity of various drugs.Structural derivatization of imidazole[1,2-a]-pyridine could be served as an important approach to obtain ATX inhibitors for pulmonary fibrotic diseases treatment.Herein,a novel series of imidazo[1,2-a]-pyridine derivatives(5a～5e,8)were designed and synthesized based on the modification site at the 6-and 3-position of amino group.The structures of all products were characterized by 1H NMR,13C NMR and MS(ESI).Then,the anti-lung fibrosis activities were evaluated in NIH/3T3 cells by CCK8 assay,which indicated that these derivatives exhibited anti-pulmonary fibrosis activity.The results demonstrated that these derivatives could be used as the potential drugs for anti-lung fibrosis.
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