Copper-catalyzed 1,3-Diborylation of Alkylidenecyclopropanes
Diboron compounds are widely used in organic synthesis,and the methods for the synthesis of such compounds have always attracted much attention.This work studied the synthesis of 1,3-dibo-ron compounds via copper catalyzed reaction of alkylidenecyclopropanes(ACPs).A series of proximal open-ring 1,3-diboron compounds(3a～3i)were synthesized using IMesCuCl as the catalyst,pinacol diborate(B2pin2)as the boron source,and lithium methoxide as the base,1,1'-binaphthyl-2,2'-bisdi-phenylphosphine as the ligand.This reaction system is compatible with different substituents(methoxy,methylthio,trifluoromethyl and benzyloxy)and benzox hetercyclic substrates.The structure of the products was characterized by 1H NMR,13 C NMR and HR-MS(ESI).
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