Synthesis and Anti-human Leukemia Cells Activities of Novel Tulipin A-oxindole-chromone Hybrids
The diversity synthesis of natural product derivative libraries based on privileged frameworks is an important research direction in the field of pharmaceutical chemistry.In this paper,based on a new synthesis strategy,we use oxindole-chromone substrates 1 with different substituents and tulipin A as starting materials,the reaction undergoes a Michael reaction to provide seven novel tulipin A-based oxindole-chromone hybrids(3a～3g)in 75％～80％yields and dr＞20∶1.The structure of product 3 was characterized by 1H NMR,13 C NMR and HR-MS(ESI-TOF).The relative configuration of com-pound 3g was further determined by single crystal X-ray diffraction.The in vitro antitumor activities a-gainst human leukemia cells(K562)were demonstrated by MTT.The results showed that compounds 3b,3e and 3f showed good cytotoxic effects.
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