Synthesis,Structure and Anticancer Activity of 8-Hydroxyquinoline Derivative's Zinc(Ⅱ)Complex
Zinc plays a crucial role in a multitude of physiological processes as the second essential trace element in living organisms.The zinc-synthesized metal complexes exhibit diverse physiological activities and possess significant regulatory functions for maintaining and optimizing bodily functions,including antitumor,antibacterial,antiviral and antioxidant properties.In this study,the 8-hydroxyquinolinederivative(8HQL)was synthesized through a Schiff base condensation reaction u-sing 8-hydroxyquinoline-2-carbaldehyde(8-HQ)and 2-hydrazino-4,6-dimethylpyrimidine(H2 L)as starting materials.By mixing the synthesized 8HQL with ZnCl2 and employing a hydrothermal method,a unique zinc(Ⅱ)complex of the Schiff base derivative of 8-hydroxyquinoline,referred to as 8HQL-Zn,was successfully prepared.The structure of this Zn(Ⅱ)complex was accurately character-ized by X-ray single crystal diffraction analysis,revealing its belonging to the rhombic crystal system with a spatial group of Pbca.Using the B3LYP calculation method in density functional theory,quan-tum chemical calculations were performed on 8HQL-Zn complex to determine the frontier orbital ener-gy distribution and band gap of 8HQL-Zn.MTT assay results demonstrated that 8HQL-Zn significant-ly inhibits the proliferation of SW480 and SY5Y tumor cells,particularly SY5Y,with an IC50 value of(6.38±0.28)μmol/L.This effect was more pronounced compared to normal LO2 cells which exhibi-ted an IC50 value of(14.35±0.39)µmol/L.Furthermore,tumor cell selectivity index(SI)analysis revealed that 8HQL-Zn exhibits favorable selectivity towards cancer cells with a selectivity index ran-ging from 1.57 to 2.25.
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