In order to improve the performance of crumb rubber modified asphalt,chloroprene rubber(CR)with a mass ratio of 11/100 to matrix asphalt and ethylene-vinyl acetate copolymer(EVA)with a mass ratio of 3/100 were used as modifiers to prepare modified asphalt.CR/EVA was activated by low-temperature plasma to further improve the perfor-mance of compound modified asphalt.The road per-formance of single modified,compound modified and low-temperature plasma activated compound modi-fied asphalt(A-CR/EVA-MA)were studied.The mi-croscopic mechanism of each modified asphalt was analyzed by scanning electron microscopy,atomic force microscopy and Fourier transform infrared spectroscopy.The results showed that the road per-formance of each modified asphalt was improved,and the overall performance of the activation modifi-cation system was better than those of compound modification and the single modification system.The penetration,softening point,ductility,Brookfield viscosity and anti-rutting factor of A-CR/EVA-MA increased by 46%,47%,94%,253%,and 278%re-spectively compared to the matrix asphalt,and the storage stability was also further improved.The low-temperature plasma activation technology increased the specific surface area and surface functional group content of the modifier,improved the adsorp-tion capacity of the modifier to the light components in the asphalt,promoted the close combination of CR,EVA and asphalt,and improved effectively the road performance of the modified asphalt.