Research progress of nucleic acid aptamers in antibiotic detection
Antibiotics,as commonly used drugs for the treatment of diseases,play a crucial role in the fields of biomedicine and public health.However,when antibiotics accumulate in a large amount in the human body through the food chain,it will cause great harm to the body.Therefore,the efficient detection of antibiotic resi-dues in food,medicine and the environment is crucial.The analysis technology based on nucleic acid aptamer sensor is a kind of simple,efficient and sensitive detection method,which has been widely used in the fields of food analysis,environmental monitoring and medical detection.This kind of method relies on a variety of enzy-matic or non-enzymatic nucleic acid amplification strategies to construct different types(fluorescence,colorimet-ric,electrochemical,etc.)nucleic acid aptamer sensors to detect different kinds of antibiotics,and realize the high sensitivity and low detection limits.This paper reviews the recent advances of nucleic acid aptamer-based sensors for the antibiotic detection,summarizes the advantages and disadvantages of these methods,and finally looks forward to the application and development of nucleic acid aptamers,and summarizes its future develop-ment trend,research focus,and challenges in future work.
万方数据
维普
