This paper analyzes the features and hazards of very fast transient overvoltage (VFTO) caused by disconnecting switch operation in GIS.Then based on a 500kV GIS substation,it established a calculation model by using electro-magnetic transient simulation software ATP-EMTP,and thereby calculated and researched the VFTO caused by disconnecting switch operation in different modes,which provides reference to reliable operation mode decision in engineering.