The research on multi-physics and multi-scale coupling of nuclear reactor is challenging and prominent in the field of nuclear energy.Especially for the large-scale,multi-dimensional and strongly nonlinear coupling system with drastic changes in physical parameters such as temperature,power and density and complex coupling conditions,the current coupling calculation codes often have problems such as slow convergence or even non-convergence,which brings many challenges and difficulties to the development of next-generation coupling computational codes.In recent years,the Virtual Reactor Coupling Analysis Team(VRCAT)at Huazhong University of Science and Technology has developed a unified coupling computational framework called Coupling Multiphysics Environment(COME)based on various coupling methods,including operator splitting,Picard iteration,and Jacobian-free Newton-Krylov(JFNK).This paper first provides a detailed analysis of the main features of COME,including the coupling methods,overall framework,and common interface.Then,based on COME,several coupling problems such as neutron transport/diffusion model,core thermal sub-channel coupling model,two-phase flow coupling model within the system analysis code and complex physical-thermal coupling model are solved respectively,and the convergence and computational efficiency of different coupling methods are compared,so as to provide method guidance and development suggestions for improving the computational stability and convergence characteristics of real complex multi-physical coupling codes.