Based on the numerical reactor physical code CRANE and sub-channel thermal hydraulic code EAGLE accelerated by GPU,a set of CRANE/EAGLE high fidelity multi-physical coupling software system was developed through direct joint compilation at the source code level.A large amount of verification and validation work has been carried out on the CRANE/EAGLE system.This paper mainly introduces the verification results of the first cycle of Tianwan Unit 5(M310 reactor)and Unit 4(VVER-1000 reactor).According to the first cycle of these two units,the calculation of starting physical parameters and the tracking simulation of operation history in days are carried out.The numerical results show that the CRANE/EAGLE code system not only has high calculation accuracy,but also can complete the multi-physics coupling calculation of a single state point of a commercial pressurized water reactor in minutes on a small multi-GPU computing platform.The CRANE/EAGLE software system verified in this paper has preliminary engineering application value.