Chiral imidazolidin-2-ones are a kind of important N-heterocycles in bioactive molecules and can be converted to valuable chiral vicinal diamines.It is of great significance to develop catalytic asymmetric transformations for the synthesis of chiral N-heterocycles which play a significant role in drug development.Herein,an asymmetric intramolecular C(sp3)-H amination of N-benzoyloxyurea via 1,5-hydrogen atom transfer(HAT)is developed by using earth-abundant iron as the catalyst and chiral amino-acid derived phenanthroline as ligand,affording a series of chiral imidazolidinones in moderate-to-good yields(up to 68%)and enantiomeric ratios(up to 81:19).It is worth noting that this is one of the very few examples of iron-catalyzed enantioselective intramolecular C(sp3)-H aminations realized with a nonenzymatic catalyst.
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