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阿魏酸-烟酰胺共晶的氢键作用及紫外光照稳定性

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制备了阿魏酸(FA)-烟酰胺(NIC)共晶,分析了FA与NIC在共晶时及溶液中的氢键作用,并研究了FA-NIC共晶中FA的水溶性和紫外光照稳定性.红外光谱和Hirshfeld表面分析结果表明,FA-NIC共晶中FA与NIC在4处位置存在氢键作用,其强弱顺序为Ⅲ(O-H···O)>Ⅰ≈Ⅱ(O···H-N)>Ⅳ(O···H-C).FA-NIC共晶中的FA比纯FA具有更低的紫外吸收和荧光强度,这说明FA-NIC共晶在水溶液中并没有完全解离,FA与NIC之间仍然存在氢键作用.相比纯 FA,FA-NIC共晶中 FA在水中的溶解度提高了 88%,FA的紫外光照稳定性提高了12.7%,两者的提高归因于FA与NIC之间的氢键作用.
Hydrogen Bonding Interactions and UV Light Stability of Ferulic Acid-Nicotinamide Cocrystals
Ferulic(FA)-niacinamide(NIC)cocrystals were prepared and the hydrogen bonding interactions between FA and NIC in cocrystalline state and aqueous solution were studied.The solubility and UV light stability of FA-NIC cocrystals were analyzed.Infrared spectra and Hirshfeld surface analyses of FA-NIC cocrystals indicated that the FA-NIC cocrystals assembled via hydrogen bonds between FA and NIC in four locations,and the intensity of the hydrogen bonds was ranked as follows:Ⅲ(O—H···O)>Ⅰ≈Ⅱ(O···H—N)>Ⅳ(O···H—C).Compared to free FA,FA-NIC cocrystals showed lower ultraviolet absorption and fluorescence intensity in aqueous solution,which suggested that the FA-NIC cocrystals did not dissociate into individual components completely and that the hydrogen bonds between NIC and FA retained in aqueous solution.By cocrystallization with NIC,the solubility of FA increased by approximately 88%,and the UV light stability of FA increased by 12.7%.This suggested that FA was easy to be solvated and difficult to change its configuration due to the hydrogen bonds between FA and NIC in cocrystals.Thus,the solubility and UV light stability of FA were demonstrated to improve remarkably by cocrystallization with NIC,which was predominantly determined by the hydrogen bonding interactions between FA and NIC.

ferulic acidcocrystalHirshfeld surface analysishydrogen bondUV light

李雨峰、井艺霏、冯海飞、王小永

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华东理工大学化学与分子工程学院,上海 200237

阿魏酸 共晶 Hirshfeld表面分析 氢键 紫外光照

2024

华东理工大学学报(自然科学版)
华东理工大学

华东理工大学学报(自然科学版)

CHSSCD北大核心
影响因子:0.289
ISSN:1006-3080
年,卷(期):2024.50(6)