首页|Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China

Vitamin D deficiency and increased inflammatory factor intercellular cell adhesion molecule-1 indicate severe leukoaraiosis in northern China

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Background and objective:Commonly plaguing in the frigid zone of the world,vitamin D deficiency,as indicated by low levels of 25-hydroxyvitamin D,exacerbated inflammatory responses and impaired endothelial function.Leukoaraiosis(LA)is a prevalent cause of cognitive dysfunction in the elderly and is potentially associated with inflammatory responses.This study aimed to investigate the impact of vitamin D on the severity of LA.Methods:Patients with LA were categorized based on 3.0 T brain MRI findings into mild(N=43),moderate(N=40),or severe groups(N=29)using the Fazekas scale(scoring 1-6).A control group consisting of 41 healthy individuals was included.Serum fibrinogen C,homocysteine,plasma 25-hydroxyvitamin D,and intercellular cell adhesion molecule-1(ICAM-1)levels were measured using ELISA.Results:All LA severity groups exhibited lower plasma 25-hydroxyvitamin D levels compared to the control group,with a more pronounced decrease observed as LA severity increased.Low plasma 25-hydroxyvitamin D was identified as an independent risk factor for LA(P＜0.05)according to Multiple logistic regression analysis.Additionally,a negative association was observed between 25-hydroxyvitamin D and vascular inflammatory factor ICAM-1.Conclusions:Disease severity positively correlated with levels of the inflammatory marker ICAM-1,worsening as plasma 25-hydroxyvitamin D concentration decreased.Low 25-hydroxyvitamin D emerged as an independent risk factor for LA,potentially exacerbating the inflammatory response.These findings suggest 25-hydroxyvitamin D supplementation as a potential therapeutic approach for LA.

cerebral small vascular diseasedegenerative diseaseleukoaraiosiswhite matter hyperintensitieslacunar infarction25-hydroxyvitamin DICAM-1fibrinogen-Cinflammatory factorfazekas scale

Jiaxin Guan、Lu Gan、Chaoqi Yan、Boyu Hou、Ying Fan

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Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China

The Physical examination center of the Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China

National Natural Science Foundation of Heilongjiang Province of ChinaKey R&D projects of Natural Science Foundation of Heilongjiang ProvinceFoundation of Harbin Science Technology Bureau of China

LH2020H0512023ZX06C032014RFQGJ042

2024

10.1515/fzm-2024-0011

寒地医学(英文)
黑龙江省卫生健康发展研究中心

寒地医学(英文)

ISSN：2096-9074
年,卷(期)：2024.4(2)