利福平/OCS-PLGA纳米缓释微球的制备及体外释放性能
Preparation and in vitro release profiles of a solid oleoylchitosan coated poly (lactic-co-glycolic acid) nanoparticles
李彦艳 1任国栋 1柳峰松 1魏建荣1
作者信息
- 1. 河北大学生命科学学院,河北保定071002
- 折叠
摘要
采用乳化溶剂蒸发法制备了油酰壳聚糖(OCS)包被的聚乙丙交酯(PLGA)纳米粒子(OCS-PL-GA NPs).采用红外光谱分析OCS-PLGA NPs.扫描电镜结果显示纳米微球形态规整、分布范围小,表面没有小孔、裂纹.PLGA浓度增大,缓释效果增强.PLGA的加入改变了疏水性内核的构造,在内核中形成网络状屏障,从而降低了药物的释放速度.OCS浓度增大,增加了纳米微球的稳定性,也增加了纳米微球外壳的厚度和致密性,增强了药物释放过程中的物理屏障,缓释效果增强.
Abstract
A solid oleoylchitosan (OCS) coated poly (lactic-co-glycolic acid) (PLGA) nanoparticles (OCS-coated PLGA NPs) were prepared using the emulsification-evaporation method.The FT-IR spectra results indicated the success of the preparation of RFP loaded OCS-coated PLGA NPs.The SEM indicated the OCS-coated PLGA NPs had regular spherical shape with narrow size distribution and smooth surface without noticeable pinholes,tiny pores or cracks.The effects of OCS concentration,PLGA concentration,and release media on drug entrapment efficiency and in vitro drug release behavior were investigated for the release properties.The RFP release rates decreased as the PLGA concentration increased.As the OCS concentration increased,the physically bound and binding affinity to RFP increased,resulting in the decrease of drug release rates.The RFP release rate was sensitive to the pH of the release media.
关键词
油酰壳聚糖/聚乙丙交酯/纳米微球/释药体系Key words
oleoylchitosan/poly (lactic-co-glycolic acid)/nanoparticles/drug delivery system引用本文复制引用
基金项目
河北省自然科学基金—石药集团医药联合研究基金(CSPC,E2013201205)
河北省高等学校科学技术研究青年基金(Q2012140)
河北省“生物学”强势特色学科项目()
2014年保定市科学技术研究与发展指导计划项目(14ZF052)
河北大学自然科学研究计划项目(2009-174)
出版年
2014
NETL
NSTL
维普
万方数据