Research progress on design strategies and structure-activity relationship of anti-Alzheimer thiazole derivatives
Thiazole is a five-membered sulfur-containing and nitrogen heterocyclic compound,which has become one of the widely used chemical frameworks in the field of medicinal chemistry due to its special structure and electronic properties and a variety of biological activities.In the past few decades,thiazole and its derivatives have shown great potential in anti-Alzheimer's research,and the chemical structure and design strategy of its derivatives are closely related to anti-Alzheimer's activity.Starting from the potential targets of Alzheimer's disease,this article reviewed the design strategies and structure-activity research progress of thiazole derivatives with anti-Alzheimer's activity in recent years based on acetylcholinesterase dominated single-target or multi-target strategies.
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