Poly culture of different aquaculture species can make full use of material resources in seawa-ter ponds,improve aquaculture water quality,increase aquaculture benefits,and promote the healthy and sustainable development of aquaculture waters.Takifugu rubripes,Mercenaria mercenarias and Fenneropenaeus chinensis were studied under the following three culture modes,including:T.ru-bripes with F.chinensis,M.mercenarias with F.chinensis,T.rubripes and M.mercenarias with F.chinensis.The growth effects of T.rubripes with M.mercenarias were analyzed,and the culture bene-fits were calculated respectively.The stocking quantity of F.chinensis under the three modes was fixed,with the initial specification of 20 000 ind./kg and the stocking density of 6 kg/hm2.At the same time,the stocking density of T.rubripes and M.mercenarias was also selected under the three modes with the highest efficiency.