A synthetic method for the active pharmaceutical ingredient iprastam,which uses glycine as the starting material and undergoes addition,substitution,and cyclization reactions to obtain the intermediate I3-carboxymethyl rhodanine were provided.Intermediate Ⅱ was obtained through condensation reaction using benzaldehyde and propanal as raw materials α-Methylcinnamaldehyde.Intermediate I and intermediate Ⅱ undergo a condensation reaction to obtain crude iparameta and refined into finished products.The total yield of the product in the entire process is over 60％,with a purity of up to 99.24％,which meets the relevant quality standards.This synthesis process has a simple route,convenient operation,simple post-treatment,and is suitable for industrial production.
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