新生儿呼吸窘迫综合征雾化吸入疗法的定量分析
Quantitative Analysis of Nebulized Inhalation Therapy for Neonatal Respiratory Distress Syndrome
刘伟华 1解谦 2周雅玲1
作者信息
- 1. 哈尔滨理工大学 理学院,哈尔滨 150080
- 2. 黑龙江省医院 儿科,哈尔滨 150036
- 折叠
摘要
新生儿呼吸窘迫综合征(NRDS)的治疗是将肺表面活性物质(PS)通过有创或无创方式作用到肺部.本文基于药物动力学原理和给药方式,建立了对新生儿无创伤的雾化吸入PS治疗NRDS的数学模型,定量分析雾化吸入PS后血氧分压(PaO2)的变化.针对新生儿雾化吸入PS用药方案,以PaO2 控制在正常值范围内为约束,数值模拟了PaO2 变化规律,发现雾化吸入与气管插管疗效相近,但无创是其优势.模型还可模拟出NRDS个性PS用药后PaO2 变化趋势,因而为临床应用雾化吸入技术提供了理论依据.
Abstract
To treat neonatal respiratory distress syndrome(NRDS)is to deliver pulmonary surfactant(PS)to lungs with either invasive or non-invasive methods.This paper,based on the pharmacokinetic principles and administration ways,established a mathematical model of nebulized inhalation of PS for the treatment of NRDS,which was non-invasive for the newborn,to quantitatively analyze the fluctuation of blood oxygen partial pressure(PaO2)after medication.For the regimen of the newborn's nebulized inhalation of PS,after simulating the variation of PaO2 with data limited within a normal range,this paper found that nebulized inhalation was similarly effective as endotracheal intubation,and that the former prevailed for its non-invasiveness.It could also simulate the changing trend of PaO2 after personal PS medication of NRDS,which has thus provided a theoretical backup for the clinical application of atomization inhalation technology.
关键词
呼吸窘迫综合征/雾化吸入数学模型/PS用药方案/PaO2数值模拟Key words
respiratory distress syndrome/mathematical model of nebulized inhalation/regimen of PS/numerical simulation of PaO2引用本文复制引用
出版年
2024
NETL
NSTL
万方数据