USP22在胃癌中的表达及其临床意义
Expression of USP22 in gastric cancer and its significance
于金玲 1杨冬冬 2郑宏群2
作者信息
- 1. 哈尔滨医科大学附属第四医院老年病科,黑龙江哈尔滨150001
- 2. 哈尔滨医科大学附属第四医院肿瘤外科,黑龙江哈尔滨150001
- 折叠
摘要
目的 检测USP22在胃癌组织中的表达,并探讨其与胃癌患者临床病理特征及预后的相关性.方法 收集125例胃癌患者的存档蜡块,应用免疫组化染色法检测USP22在正常胃黏膜组织及胃癌组织中的表达,并采用SPSS 13.0软件对结果进行统计学分析.结果 USP22在胃癌组织的阳性表达率高于正常组织;USP22的表达与患者的年龄、性别、肿瘤大小无相关性,而与肿瘤分化程度、浸润深度、有无淋巴结转移、有无远处转移以及MCC临床分期相关(P＜0.05);USP22阴性表达的患者5年生存率明显高于阳性表达组(P＜0.05).结论 USP22在胃癌的发生、发展过程中起到了一定作用,USP22蛋白高表达的胃癌患者预后差.
Abstract
Objective To investigate the expression of USP22 in gastric cancer and to explore its correlation with the occurrence,development and prognosis of gastric cancer.Methods Immunohistochemical staining was used to detect the expression of USP22 in normal gastric mucosa and cancer.And the experimental data were statistically analyzed through SPSS 13.0 software.Results The expression of USP22 was upregulated in gastric cancer tissue compared with normal tissue (P ＜ 0.05).The expression of USP22 was not associated with age,sex and the size of tumor,but with the differentiation level,the depth of invasion,metastatic lymph nodes and AJCC clinical staging.The increased expression of USP22 was associated with low five-year survival rate (P ＜ 0.05).Conclusion USP22 should play a significant role in tumorigenesis and progression of gastric cancer,the patients with high expression of USP22 may be suggest a poor prognosis.
关键词
胃癌/USP22/免疫组化Key words
gastric cancer/USP22/immunohistochemistry引用本文复制引用
基金项目
黑龙江省卫生厅科研课题(2013105)
黑龙江省卫生厅科研课题(2013106)
黑龙江省青年科学基金(QC2012C019)
出版年
2016
NETL
NSTL
维普
万方数据