Effect of capsaicin on inflammatory pain and spinal TRPV1 expression in rats
Objective To observe the analgesic effect of capsaicin on rats with inflammatory pain,and to explore its possible mechanism.Methods Twenty-six rats were divided into 4 groups according to random number method,namely control group(5 cases),model group(7 cases),low-dose group(7 cases)and high-dose group(7 cases).The rats in the model group and the administration group were subcutaneously injected with 100 μL complete Freund's ad-juvant(CFA)in the middle of the foot plantar to establish a chronic inflammatory pain model.The mechanical pain threshold of sexual pain rats was induced by acetone spray method and the pain degree was scored.The expression of transient receptor potential vanilloid-1(TRPV1)pro-tein in dorsal root ganglion(DRG)tissues of rats was detected by immunohistochemical SP method.Results Capsaicin increased the mechanical pain threshold and cold pain threshold of the rats in the model group(P＜0.05),and decreased the expression of TRPV1 protein in the DRG tissue of the rats.Conclusion Capsaicin has analgesic effect on the chronic inflam-matory pain induced by CFA in rats,and its mechanism may be related to the down-regulation of TRPV1 protein expression.
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