摘要
目的 探讨胃肠道间质瘤(gastrointestinal stromal tumor,GIST)出血、坏死、囊性变与临床病理参数相关性.方法 回顾性分析2016年1月～2021年12月就诊于哈尔滨医科大学附属肿瘤医院的46例GIST患者的完整临床资料,包括性别、年龄、肿瘤大小、有丝分裂指数、形态表型、危险度分级、Ki67指数、出血、坏死、囊性变、新辅助治疗、复发转移情况.分析出血、坏死、囊性变、Ki67指数与各个参数之间关系.结果 肿瘤出血、坏死均与有丝分裂指数、新辅助治疗情况之间差异有统计学差异(P＜0.05). Ki67指数与出血、坏死、有丝分裂指数、危险度分级之间差异存在统计学差异(P＜0.05).单因素分析发现,危险度分级、肿瘤大小、有丝分裂指数、Ki67指数与GIST预后相关(P＜0.05).多因素分析结果显示,危险度分级及有丝分裂指数是GIST患者预后的独立危险因素(P＜0.05).结论 Ki67指数与肿瘤出血、坏死、有丝分裂指数、危险程度、复发转移均密切相关,危险度分级及有丝分裂指数可作为GIST患者的独立预后因素.
Abstract
Objective To investigate the relationship between bleeding,necrosis,cystic de-generation and clinicopathological parameters in gastrointestinal stromal tumor(GIST).Meth-ods The clinical data of 46 patients with GIST in Harbin Medical University Cancer Hospital from January 2016 to December 2021 were retrospectively analyzed,including gender,age,tumor size,mitotic index,morphological phenotype,risk classification,Ki67 index,bleeding,necrosis,cystic degeneration,neoadjuvant therapy,recurrence and metastasis.The relation-ship between bleeding,necrosis,cystic denegeration,Ki67 index,and various parameters were analyzed.Results There were significant differences between tumor hemorrhage and necrosis and mitotic index,neoadjuvant therapy(P＜0.05).There were significant differences between Ki67 index and bleeding,necrosis,mitotic index and risk classification(P＜0.05).Univari-ate analysis showed that risk classification,tumor size,mitotic index and Ki67 index were re-lated to the prognosis of GIST(P＜0.05).Multivariate analysis showed that risk grade and mitotic index were independent risk factors for the prognosis of GIST patients(P＜0.05).Conclusion Ki67 index is closely related to tumor bleeding,necrosis,mitotic index,risk grade,recurrence and metastasis.Risk grade and mitotic index can be used as independent prognostic factors for GIST patients.
NETL
NSTL
万方数据