Investigation and analysis of perinatal risk factors for early onset neonatal sepsis and establishment of prediction model
Objective To explore the perinatal risk factors of early onset neonatal sepsis and establish a predictive model.Methods A total of 66 children with early-onset neonatal sepsis who were born in our hospital from June 2020 to February 2022 were selected to be included in the study group,and 50 newborns without sepsis diagnosis hospitalized in the neonatology de-partment of our hospital were selected to be included in the control group.Clinical data of the two groups of children were collected to explore the factors affecting the occurrence of early-on-set neonatal sepsis,and the corresponding prediction model was established.Results Com-pared with mothers without a diagnosis of sepsis,the mothers with early-onset neonatal sepsis had older gestation age,more abortion history,abnormal placenta,abnormal amniotic fluid vol-ume,premature rupture of membranes,and prenatal fever(P＜0.05).The proportion of pre-mature infants,low body weight and very low body weight,wet lung with early onset neonatal sepsis was higher(P＜0.05).Maternal gestational age over 35 years old,prenatal fever,pre-mature birth,low birth weight and very low birth weight all affected the occurrence of early-on-set neonatal sepsis(P＜0.05).According to the prediction model,57 of the 116 neonates were diagnosed as normal and 59 were diagnosed as early-onset neonatal sepsis.With clinical diagnosis as the gold standard,the accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of early onset neonatal sepsis were 87.07％,83.33％,92.00％,93.22％,and 80.70％respectively.Conclusion Maternal gestational age over 35 years old,prenatal fever,premature birth,low birth weight and very low birth weight may affect the oc-currence of early-onset neonatal sepsis,and should be paid close attention to.The predictive model established in this study has certain diagnostic value and can assist in the diagnosis of early-onset neonatal sepsis.
early onset neonatal sepsisrisk factorsprediction modelperinatal period
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